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Old, Cheap Steroids Help with COVID Respiratory Issues

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19

https://www.recoverytrial.net/files/recovery_dexamethasone_statement_160620_v2final.pdf
It’s not a controlled study. But....I will say that my son each year (usually around late fall or early winter) has an issue with respiratory distress that looks like asthma. In the ER the albuterol only marginally helps. Dexamethasone, once administered (swallowed in a slurry) fixes him in under an hour. It’s like a miracle drug for respiratory distress.
 
It’s not a controlled study.
yes, it was

The only issue with the study is that the results are parsed out in a press release rather than in a peer-reviewed scientific article, showing all methods & details

synopsis:
2104 patients, either on ventilation or receiving supplemental oxygen, were given 6mg dexamethasone (oral or i.v.) daily for ten days.

Comparing them with 4321 patients on standard-of-care, the death rates definitely decreased with dexamethasone: the 28-day mortality for patients on ventilation with standard of care was 41%, and dex treatment decreased that to 27%.

For patients receiving supplemental oxygen, the 28-day mortality was 25%, which decreased to 20% with dex.

The 28-day mortality for patients who needed no respiratory intervention, the 28-day mortality was 13%, and dexamethasone had no effect on that whatsoever.

p-values and confidence intervals for the first 2 groups (on ventilation or receiving supplemental oxygen) were very good indeed, as one would hope from the large number of patients.

Summary here: https://blogs.sciencemag.org/pipeline/archives/2020/06/17/dexamethasone-for-coronavirus-infection
 
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yes, it was

The only issue with the study is that the results are parsed out in a press release rather than in a peer-reviewed scientific article, showing all methods & details

synopsis:
2104 patients, either on ventilation or receiving supplemental oxygen, were given 6mg dexamethasone (oral or i.v.) daily for ten days.

Comparing them with 4321 patients on standard-of-care, the death rates definitely decreased with dexamethasone: the 28-day mortality for patients on ventilation with standard of care was 41%, and dex treatment decreased that to 27%.

For patients receiving supplemental oxygen, the 28-day mortality was 25%, which decreased to 20% with dex.

The 28-day mortality for patients who needed no respiratory intervention, the 28-day mortality was 13%, and dexamethasone had no effect on that whatsoever.

p-values and confidence intervals for the first 2 groups (on ventilation or receiving supplemental oxygen) were very good indeed, as one would hope from the large number of patients.

Summary here: https://blogs.sciencemag.org/pipeline/archives/2020/06/17/dexamethasone-for-coronavirus-infection
I read another press release that didn’t mention what sounded like a study. Glad it’s real.
 
It’s not a controlled study. But....I will say that my son each year (usually around late fall or early winter) has an issue with respiratory distress that looks like asthma. In the ER the albuterol only marginally helps. Dexamethasone, once administered (swallowed in a slurry) fixes him in under an hour. It’s like a miracle drug for respiratory distress.

Hope that your son's respiratory issues are controlled. That kind of thing is really hard on both the kid and parents.
 
The Vid was the worst Btown bar of all time, much like you as a poster.
Probably a good example as to why you and me don’t agree on much, and that’s fine. We used to drink there often and then stroll over to Sports during 2am cleanup hour to rescue lonely girls from douche bag chumps like you.

ESAD
 
Probably a good example as to why you and me don’t agree on much, and that’s fine. We used to drink there often and then stroll over to Sports during 2am cleanup hour to rescue lonely girls from douche bag chumps like you.

ESAD

Your insecurity is showing. Are you related to hoops? You guys can both be infertile idiots together.
 
Hope that your son's respiratory issues are controlled. That kind of thing is really hard on both the kid and parents.
Thanks. It’s literally one time a year. Last one was very bad...we’re irrationally hoping it was his last. His older brother had it and outgrew it.
 
Thanks. It’s literally one time a year. Last one was very bad...we’re irrationally hoping it was his last. His older brother had it and outgrew it.
How old is you son? Our son (now 16) used to have pretty severe issues when he was young. They would usually diagnose it as croop, but I think they sometimes did that just because they had nothing else that seemed to fit. They would always prescribe prednisone (another corticosteroid), but sometime he got dexamethasone instead. We used to always have a bottle of prednisone in our refrigerator just in case he had an episode at night. It was pretty scary at times, and I remember sitting with him in the bathroom, with the shower running full hot to make a steam room to help him. I think he grew out of it at ~6-7 years old.

For point of reference, this is our son who has Down syndrome. My layman's theory was that the problems were all caused by anatomical issues, specifically smaller airways in his lungs. I think someone must have mentioned that to me as a possibility once. But, over the last 16 years I have learned that Down syndrome can manifest itself in all kinds of different (and unusual) ways, often stumping doctors. There are simply things they do not know. Thankfully, all of those issues currently are nothing overly concerning.
 
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How old is you son? Our son (now 16) used to have pretty severe issues when he was young. They would usually diagnose it as croop, but I think they sometimes did that just because they had nothing else that seemed to fit. They would always prescribe prednisone (another corticosteroid), but sometime he got dexamethasone instead. We used to always have a bottle of prednisone in our refrigerator just in case he had an episode at night. It was pretty scary at times, and I remember sitting with him in the bathroom, with the shower running full hot to make a steam room to help him. I think he grew out of it at ~6-7 years old.

For point of reference, this is our son who has Down syndrome. My layman's theory was that the problems were all caused by anatomical issues, specifically smaller airways in his lungs. I think someone must have mentioned that to me as a possibility once. But, over the last 16 years I have learned that Down syndrome can manifest itself in all kinds of different (and unusual) ways, often stumping doctors. There are simply things they do not know. Thankfully, all of those issues currently are nothing overly concerning.
He’s 7. Your experience is the same as ours. Shower Running and fingers crossed. It’s not cool.
 
He’s 7. Your experience is the same as ours. Shower Running and fingers crossed. It’s not cool.
My boy is three and goes through this often. Last time we had to rush him to the hospital was the same day that Trump said anyone who needs a test can get a test.
His oxygen level was 83 %. They gave him two epi pens and multiple steroid treatments. They said he was in fight or flight mode.
This was at 3 am. It’s always in the dead of night. I was begging him to keep trying to breathe on the way to the hospital.
We’ve done the steam shower and carried him outside to breathe too many times to count.
It’s a huge dose of reality. Breaks your heart.
 
It’s not a controlled study. But....I will say that my son each year (usually around late fall or early winter) has an issue with respiratory distress that looks like asthma. In the ER the albuterol only marginally helps. Dexamethasone, once administered (swallowed in a slurry) fixes him in under an hour. It’s like a miracle drug for respiratory distress.

My boy is three and goes through this often. Last time we had to rush him to the hospital was the same day that Trump said anyone who needs a test can get a test.
His oxygen level was 83 %. They gave him two epi pens and multiple steroid treatments. They said he was in fight or flight mode.
This was at 3 am. It’s always in the dead of night. I was begging him to keep trying to breathe on the way to the hospital.
We’ve done the steam shower and carried him outside to breathe too many times to count.
It’s a huge dose of reality. Breaks your heart.

How old is you son? Our son (now 16) used to have pretty severe issues when he was young. They would usually diagnose it as croop, but I think they sometimes did that just because they had nothing else that seemed to fit. They would always prescribe prednisone (another corticosteroid), but sometime he got dexamethasone instead. We used to always have a bottle of prednisone in our refrigerator just in case he had an episode at night. It was pretty scary at times, and I remember sitting with him in the bathroom, with the shower running full hot to make a steam room to help him. I think he grew out of it at ~6-7 years old.

For point of reference, this is our son who has Down syndrome. My layman's theory was that the problems were all caused by anatomical issues, specifically smaller airways in his lungs. I think someone must have mentioned that to me as a possibility once. But, over the last 16 years I have learned that Down syndrome can manifest itself in all kinds of different (and unusual) ways, often stumping doctors. There are simply things they do not know. Thankfully, all of those issues currently are nothing overly concerning.

Have you guys ever looked into biologics with an allergy and asthma physician? I've read/heard about some amazing developments on those fronts, but know they are related to specific asthma and ID issues.
 
My boy is three and goes through this often. Last time we had to rush him to the hospital was the same day that Trump said anyone who needs a test can get a test.
His oxygen level was 83 %. They gave him two epi pens and multiple steroid treatments. They said he was in fight or flight mode.
This was at 3 am. It’s always in the dead of night. I was begging him to keep trying to breathe on the way to the hospital.
We’ve done the steam shower and carried him outside to breathe too many times to count.
It’s a huge dose of reality. Breaks your heart.

God damn, you deserve a metal. That's some tough shit. I hope he gets better and outgrows it.
 
My boy is three and goes through this often. Last time we had to rush him to the hospital was the same day that Trump said anyone who needs a test can get a test.
His oxygen level was 83 %. They gave him two epi pens and multiple steroid treatments. They said he was in fight or flight mode.
This was at 3 am. It’s always in the dead of night. I was begging him to keep trying to breathe on the way to the hospital.
We’ve done the steam shower and carried him outside to breathe too many times to count.
It’s a huge dose of reality. Breaks your heart.


Wow, so sorry you are dealing with this. That sounds truly awful.
 
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My boy is three and goes through this often. Last time we had to rush him to the hospital was the same day that Trump said anyone who needs a test can get a test.
His oxygen level was 83 %. They gave him two epi pens and multiple steroid treatments. They said he was in fight or flight mode.
This was at 3 am. It’s always in the dead of night. I was begging him to keep trying to breathe on the way to the hospital.
We’ve done the steam shower and carried him outside to breathe too many times to count.
It’s a huge dose of reality. Breaks your heart.
When it oldest was just a baby we went through the same thing. Scary as hell but he out grew it and hopefully yours will as well. The first time we did the steamy bathroom/outdoor thing it was twenty two below zero.
We lived in Minnesota at the time.
 
When it oldest was just a baby we went through the same thing. Scary as hell but he out grew it and hopefully yours will as well. The first time we did the steamy bathroom/outdoor thing it was twenty two below zero.
We lived in Minnesota at the time.
Wow. I’ve wrapped him up and taken him out in the bitter cold, but not close to that.
 
When it oldest was just a baby we went through the same thing. Scary as hell but he out grew it and hopefully yours will as well. The first time we did the steamy bathroom/outdoor thing it was twenty two below zero.
We lived in Minnesota at the time.

That's a typical night up here! My daughter is a winter bday and on her literal first birthday, I had to take her to the ED of a children's hospital at 2am b/c she was at 105 temp.

If I recall it was in the 20 or 30 below range, but I didn't even notice. Amazing what doesn't phase you when there are real problems and issues you are dealing with.
 
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My boy is three and goes through this often. Last time we had to rush him to the hospital was the same day that Trump said anyone who needs a test can get a test.
His oxygen level was 83 %. They gave him two epi pens and multiple steroid treatments. They said he was in fight or flight mode.
This was at 3 am. It’s always in the dead of night. I was begging him to keep trying to breathe on the way to the hospital.
We’ve done the steam shower and carried him outside to breathe too many times to count.
It’s a huge dose of reality. Breaks your heart.
It’s utterly heartbreaking. Especially because we never had these issues as kids. Something is happening to the health of our kids out of nowhere and It sucks.
 
It’s utterly heartbreaking. Especially because we never had these issues as kids. Something is happening to the health of our kids out of nowhere and It sucks.
That may be. My boy was born a month early and was on oxygen for nearly a week, so I don’t think I can do anything but be grateful for the doctors and nurses. I’ve met some really great people due to these sorts of issues. They’re out there.
 
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Have you guys ever looked into biologics with an allergy and asthma physician? I've read/heard about some amazing developments on those fronts, but know they are related to specific asthma and ID issues.
Well ours has long grown out of it. At the time, I do not believe any of the docs thought it was allergies or asthma related. Instead, it was likely just the way his own unique body and his immune system reacted to something like a common cold or other respiratory infection. I do recall some breathing treatments from time to time, but the steroids always seem to work the best (and with few, if any, side effects). We are blessed to live in Cincinnati, which has one of the finest children's hospitals in the world (including its Thomas Center for Down Syndrome Services). Combine that with an extraordinary local Down syndrome association and we are in the perfect place.
 
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That may be. My boy was born a month early and was on oxygen for nearly a week, so I don’t think I can do anything but be grateful for the doctors and nurses. I’ve met some really great people due to these sorts of issues. They’re out there.

Yes sir - same here.

When our son was around 3 he had his tonsils and adenoids removed. He ended up staying at Cincinnati Children's Hospital for a couple of nights due to low oxygen levels (probably from swelling). We were absolutely miserable and feeling sorry for ourselves and our son - until we found out that most of the kids in the rooms around us had been there for a month or more, being treated for life-threatening conditions (e.g., leukemia). It was the week after Christmas. Talk about an attitude adjuster. We felt guilty being able to leave on the third day. It was hard to keep it together as we left, knowing what the families in adjacent rooms were still facing.

In March we had an appointment where they needed to draw blood from our son. Our other two would be basket cases for days before something like that (including our 18 year old). Our middle son, however, is fascinated by it. (I've even seen him watch phlebotomy videos on YouTube.) But the nurses at Children's didn't know that, so they were in their usual mode of making a child comfortable when someone is about to jab a needle into their vein and leave it there for several minutes while they suck out a gazillion vials. (Can you tell that I don't like it either?) I think there were four nurses/aids in the room, each with their own role. Their routine was remarkable, and I could tell that their number one goal was keeping the child calm and comfortable. Heck, I wish I could go there when I need to have a blood draw!

I also love that Cincinnati Children's actually hires individuals who have a developmental disability. One friend of ours, Mary, has worked there for years as a patient transporter. She told me once that she typically logs over 10 miles a day, often taking discharged patients from their room to the front entrance. Other individuals with a developmental disability work in their food service, and I know of one that I believe works as a lab assistant. Inspiring stuff.

A children's hospital is an extraordinary place, filled with amazing doctors, nurses and staff. I doubt that just any doctor or nurse has was it takes to work at one. Rather, it requires a unique breed.I hope and pray that your son soon grows out of what you described.
 
I also love that Cincinnati Children's actually hires individuals who have a developmental disability. One friend of ours, Mary, has worked there for years as a patient transporter. She told me once that she typically logs over 10 miles a day, often taking discharged patients from their room to the front entrance. Other individuals with a developmental disability work in their food service, and I know of one that I believe works as a lab assistant. Inspiring stuff.

This is great stuff. They get a valuable purpose, get paid to do it and get keep physically active!
 
This is great stuff. They get a valuable purpose, get paid to do it and get keep physically active!
That’s rather patronizing and condescending. These are real jobs.
And “physically active”? Heck I’d be willing to bet that my friend Mary could run circles around you. She’s run multiple marathons. Last year she ran the three way Flying Pig weekend - 5k, 10k, and marathon races in two days.
What’s your “valuable purpose”?
 
That’s rather patronizing and condescending. These are real jobs.
And “physically active”? Heck I’d be willing to bet that my friend Mary could run circles around you. She’s run multiple marathons. Last year she ran the three way Flying Pig weekend - 5k, 10k, and marathon races in two days.
What’s your “valuable purpose”?
I can't remember if I asked you this, but is your son still slinging spatulas?
 
That’s rather patronizing and condescending. These are real jobs.
And “physically active”? Heck I’d be willing to bet that my friend Mary could run circles around you. She’s run multiple marathons. Last year she ran the three way Flying Pig weekend - 5k, 10k, and marathon races in two days.
What’s your “valuable purpose”?
Are you sure you’re not taking him way out of context?
 
I'm not a specialist or nutritionist, but I'm sure we should never use steroids in the treatment of COVID-19. It's a total aberration. How can we treat a virus that affects the respiratory system primarily with some steroids? The total rumors spread by TRUMP's supporters.
 
I'm not a specialist or nutritionist, but I'm sure we should never use steroids in the treatment of COVID-19. It's a total aberration. How can we treat a virus that affects the respiratory system primarily with some steroids? The total rumors spread by TRUMP's supporters.

I don't think this publication is known to be published by TRUMP supporters...


You need to get your Donald Trump Syndrome under control before you concern yourself with anyone else's course of treatment for COVID19...
 
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I'm not a specialist or nutritionist, but I'm sure we should never use steroids in the treatment of COVID-19. It's a total aberration. How can we treat a virus that affects the respiratory system primarily with some steroids? The total rumors spread by TRUMP's supporters.

in other words, you have zero idea what you are talking about
 
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