Depends on the location, because the answer is "This pub offers what no other bar in the area does."
The way I came out on top all those years ago in Perrysburg was basically getting ahead of the fads. I read that bars in New York and Chicago were diving head first into rye, so I loaded up on rye as soon as Ohio offered it, put together a special classic cocktails drink list, and for a while, we had the only bar in the area you could buy that stuff. When the big cities started dumping mass-produced mixers, I followed suit. We made sour mix every morning from scratch. I got rid of Rose's, and every two weeks, I'd make syrups of reduced Pom and Nellie & Joe's. We got a big ass container and infused vodka with various hot peppers as a base for our Bloody Marys. Every fall, I'd buy a boat load of cherries and bring in the staff for a cherry-pitting party. Then we'd soak them in cambros of brandy and sugar, and serve them all year. No neon-red cherries from us.
It cost more on labor, but in most cases, the ingredients were actually cheaper (lemons and sugar are way cheaper than Dailey's sour mix, for example), and I could actually charge more for a cheaper drink because it was unique, and usually tasted better.
As often happens with success, every time we did one of these things, some bars would start copying us, and we'd lose that edge. So we just kept moving to the next thing. I don't think other bar managers and owners read the industry mags like we did, so once it was happening in New York, Chicago, Atlanta, and we found out about it, it was happening with us, too. A lot of times, we even got in on the new fads before bars in Cleveland were even doing it.
Fort Wayne is seriously behind Toledo in bar culture. By at least a decade. So I think if I opened up here, I could recycle some of those things, but ultimately, the trick is to always be pushing the envelope.