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Omicron "variant of concern"

Why you should upgrade your mask as the Omicron variant spreads - CNN
 
Why you should upgrade your mask as the Omicron variant spreads - CNN

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I get the idea that unvaxxed should be "punished" by moving to the back of a line. It actually fits the conservative implied suggestions that it's somewhat okay for people with diabetes to die because it's their fault anyway. Americans love to see what they perceive as wrongdoing punished. But medicine must remain neutral, normal triage must apply.
DM is a disease CAUSED by genetics but requires a dietary input to manifest itself….Without the diabetic genotype, one can eat sugar/calories by the shovel full and BS will never go above normal nor will any of the complications of DM appear….CV disease is closely allied to DM (DM is really a disease affecting blood vessels). The association of CV disease with chol (levels are genetically determined and influenced by diet only minimally) is pretty weak….Eg- diabetics have MIs at a rate of about 60/1000/yr compared to non-diabetics at 4/1000/yr…Hi chol raises the rate to 8/1000/yr
 
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What little I know about the differences between the two make me think the mRNA derived vaccines would be more benign, but that's just a gut reaction.
To develop a vaccine the old fashioned way, one has to first find a way of rendering the virus weakened or dead, then seeing if it not only brings on the desired immunity, but also doesn’t cause disease (if live)— it is after all the virus itself….All time consuming and hit & miss experimentation.

The mRNA technique is an elegant application of basic science— Manufacture the antigen and then test to see if it works. Cuts out a lot of the middle man experimentation…OTOH- one weakness is that it’s only one antigen compared to multiple antigens on the virus itself…. The remedy will be to manufacture vaxes with multiple mRNAs.
 
Realistically, how many more mutations can we expect from covid? Is there any way to even guess?
Everyone knows about the problem of antibiotic resistance—> If an antibiotic is given, it kills all the bugs that can be killed by it, leaving behind mutants (not causing them, just leaving them behind) that are resistant to that antibiotic. Pretty soon, the only bugs left in the world are the ones resistant to that antibiotic. It becomes useless in the medical armamentarium.

Same thing for vaccines—> any mutant (“variant”) not killed off by the vax will soon become the dominant type if everyone is vaccinated…I guess we’ll never know how much of the changing viral gene frequency is due to natural factors vs increased selection pressure caused by the vaccine.

It’s not a “black & white” choice about using vaccines. Being such a “leaky” vaccine, it may actually be prolonging the pandemic by encouraging new mutants.
 
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Being such a “leaky” vaccine, it may actually be prolonging the pandemic by encouraging new mutants.
All of the mutations we're currently dealing with emerged well before the COVID-19 vaccines were publicly available. Every one. Including omicron.

 

 
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All of the mutations we're currently dealing with emerged well before the COVID-19 vaccines were publicly available. Every one. Including omicron.

Omicron was discovered in Nov of 21. It's not mentioned in that article you posted. Is there a difference between discovered and what your article refers to as earliest sample date?
 
Omicron was discovered in Nov of 21. It's not mentioned in that article you posted. Is there a difference between discovered and what your article refers to as earliest sample date?
It was discovered recently, but its genetic lineage dates back at least to early 2021
 
It was discovered recently, but its genetic lineage dates back at least to early 2021
The fact that they're mutations from the original means they all have that lineage, right?

I'm asking if the mutation that has been identified as Omicron really predates the use of vaccines.
 
The fact that they're mutations from the original means they all have that lineage, right?

I'm asking if the mutation that has been identified as Omicron really predates the use of vaccines.
One of the threads MTIOTF started suggested omicron was a variant off the original and went into mice in the summer of 2020. That is of course just one theory.

But omicron does lack some of the mutations delta had, so we believe it predates delta
 
One of the threads MTIOTF started suggested omicron was a variant off the original and went into mice in the summer of 2020. That is of course just one theory.

But omicron does lack some of the mutations delta had, so we believe it predates delta
Thanks. Hadn't heard the mice theory. I know some Penn State researchers found that deer are carrying the virus, but I haven't really gone and looked for info on transmission across or between species.
 


 
Thanks. Hadn't heard the mice theory. I know some Penn State researchers found that deer are carrying the virus, but I haven't really gone and looked for info on transmission across or between species.
I think it was a Leopard at a zoo in Michigan that just died from Sars-cor-2.

The mice theory is intriguing, it will be interesting to see if more scientists buy into the theory.
 
OK, let's apply some common sense.

Mutations occur through viral replication. The more copies of the virus there, the more mutation occurs. It is spontaneous and random. A given mutation frequency.

If population A, unvaccinated, has a viral load 10x that of population B, who is vaccinated, the odds of random mutation to any specific variant is clearly higher in population A. Both would be susceptible to the properties of the mutant, so there is no selective pressure with respect to population B.

If vaccination was driving mutation, mutants would be first arising in highly vaccinated populations (Israel, as an example). To date, the opposite is true. Mutants arise in largely unvaccinated populations and then spread to the vaccinated populations, if mutation creates a more vaccine-resitant variant by chance.
 
Deaths spiking in 3 cities on front edge of Omicron infection surge (though not as high as prior infection surges).

 
I don't have an NYT account. Which 3 cities?
Here's an excerpt:

"In New York City, Boston and Chicago — cities with some of the country’s earliest Omicron surges — deaths have followed cases at a slightly reduced scale than in previous peaks. But because of the extraordinarily high case count, even a proportionally lower death toll from the current case curve in the United States could be devastating.

In early-hit cities, hospitals are seeing more patients testing positive for Covid-19 than at any time last year. Because of the sheer infectiousness of the Omicron variant, many who arrive at the hospital for other ailments test positive for the coronavirus. Some doctors have also said that patients who do have Covid as a primary diagnosis are faring better than during previous waves.

Even so, the number of Covid-19 patients who need intensive care or mechanical ventilation is approaching levels not seen since last winter. And the sheer number of patients is overwhelming to hospitals, where staffing shortages are putting healthcare workers under immense strain."
 
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