This is a JAMA just-published study from Columbia University.
Almost 5,000 patients were followed. While the median time for recovery was 20 days, 1 in 5 took more than 90 days to be free of COVID symptoms. Several factors were found to be associated with prolonged COVID recovery time. There was a longer time to recovery if you are…
-unvaccinated (the affect of boosters was less clear; the authors state that the boosted patient population was underpowered)
-a woman (Curiously, women report on average less severe illness but more prolonged / lingering symptoms)
-an American Indian or Alaska Native
-a person with pre-existing cardiovascular disease (CVD)
-a person who was infected earlier in the pandemic, pre-omicron
There were other categories with no statistical difference upon time to recovery, including if you are…
-a diabetic (somewhat surprising)
-a person with chronic lung disease (also surprising)
-a person with diagnosed mental health disorders
The paper's conclusions paragraph, verbatim: This cohort study found that 1 in 5 adults infected with SARS-CoV-2 did not fully recover by 3 months post infection in a racially and ethnically diverse US population-based sample. Recovery by 90 days was less likely in women and participants with prepandemic clinical CVD. Vaccination prior to infection and infection during the Omicron variant wave were associated with greater recovery, which was partially mediated by reduced acute infection severity. Results were similar for reinfections. Further investigation on the longer-term prognosis and mechanisms of PCC, including comparisons of multiorgan structure and function before and after infection, is critical to inform treatment and prevention.
Almost 5,000 patients were followed. While the median time for recovery was 20 days, 1 in 5 took more than 90 days to be free of COVID symptoms. Several factors were found to be associated with prolonged COVID recovery time. There was a longer time to recovery if you are…
-unvaccinated (the affect of boosters was less clear; the authors state that the boosted patient population was underpowered)
-a woman (Curiously, women report on average less severe illness but more prolonged / lingering symptoms)
-an American Indian or Alaska Native
-a person with pre-existing cardiovascular disease (CVD)
-a person who was infected earlier in the pandemic, pre-omicron
There were other categories with no statistical difference upon time to recovery, including if you are…
-a diabetic (somewhat surprising)
-a person with chronic lung disease (also surprising)
-a person with diagnosed mental health disorders
The paper's conclusions paragraph, verbatim: This cohort study found that 1 in 5 adults infected with SARS-CoV-2 did not fully recover by 3 months post infection in a racially and ethnically diverse US population-based sample. Recovery by 90 days was less likely in women and participants with prepandemic clinical CVD. Vaccination prior to infection and infection during the Omicron variant wave were associated with greater recovery, which was partially mediated by reduced acute infection severity. Results were similar for reinfections. Further investigation on the longer-term prognosis and mechanisms of PCC, including comparisons of multiorgan structure and function before and after infection, is critical to inform treatment and prevention.
Epidemiologic Features of Recovery From SARS-CoV-2 Infection
This cohort study examines the association between certain health conditions and lifestyle factors with time to recovery from SARS-CoV-2 infection in a US population-based meta-cohort.
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