Pass interference is the most misapplied and costly penalty in the sport. Often, the referees feel the pressure of the home crowd. I bet if you looked at all the interference calls over a season, the majority would be in the home team's favor. I think interference is similar to charging in basketball, usually just one person's opinion. Interference is even worse in the NFL, where the ball is placed "at the spot of the foul." It's also aggravating when the crowd starts moaning for the refs to "throw the flag." I think games decided by these calls are cheapened; I would like to see the criteria for the penalty changed. Either it's holding, similar to what linemen do, or it is called if the defender tackles the receiver, but most other contact should be allowed. I also think interference penalties should be eligible for challenges and video review. On another note, penalties should only result in an "automatic first down," if the penalty yardage exceeds the "line to gain." If it's 3rd and 20 and the defense is called for a 15-yard penalty, then it should be 3rd and 5.