Remdesivir showing early promise in Chicago study

[Marvin the Martian]

This is exactly what I've been wondering. I'm not hearing any estimates of impact on actual death rates.

Gupta was discussing it, I do not recall the numbers but they were slight and his reference was "not statistically significant".

 

[bawlmer]

IIUC, this is provided intravenously over a 5 or 10 day period. Can't imagine how you'd do that on an outpatient basis at scale.

Right now if you test Covid positive you're told to quarantine and it's hoped you don't crash. Perhaps those who test positive could be given this regimen as a matter of course, no matter how symptomatic you are. But then we're back to the supply and capacity concerns...

A closely related oral drug is also in testing: link. This could allow earlier treatment, which could improve effectiveness.

 

[JamieDimonsBalls]

IIUC, this is provided intravenously over a 5 or 10 day period. Can't imagine how you'd do that on an outpatient basis at scale.

Right now if you test Covid positive you're told to quarantine and it's hoped you don't crash. Perhaps those who test positive could be given this regimen as a matter of course, no matter how symptomatic you are. But then we're back to the supply and capacity concerns...

That's not necessary. You want people, that can, to build immunity naturally and overcome the disease without the need for medicine, keeping the supply available for those with underlying conditions.

Intravenously - doesn't that include injections and not just IV drips? Drip treatments make it more difficult, but there are some that have a shorter duration.

 

[outside shooter]

Death rate was 8% on the drug, 11% on placebo. The size if the sample wasn't large enough to establish that the difference between 8% and 11% has statistical significance.

 

[anon_mlxxvlbug9dpa]

That's not necessary. You want people, that can, to build immunity naturally and overcome the disease without the need for medicine, keeping the supply available for those with underlying conditions.

Intravenously - doesn't that include injections and not just IV drips? Drip treatments make it more difficult, but there are some that have a shorter duration.

Intravenous would include injections but usually means infusion. What you think of as an injection like the flu shot is “intramuscular” not intravenous.

 

[twenty02]

That's not necessary. You want people, that can, to build immunity naturally and overcome the disease without the need for medicine, keeping the supply available for those with underlying conditions.

Intravenously - doesn't that include injections and not just IV drips? Drip treatments make it more difficult, but there are some that have a shorter duration.

This drug is administered via IV drip (2 hours) .. and for repeated days. It doesn't seem plausible outside of an inpatient hospital setting.

 

[JamieDimonsBalls]

This drug is administered via IV drip (2 hours) .. and for repeated days. It doesn't seem plausible outside of an inpatient hospital setting.

That's actually not that long of a time period. Patients get infusions at specialty pharmacies, centers, etc. where they can get treatment. What I don't know are the side affects as it relates to being able to commute to/from.

 

[twenty02]

That's actually not that long of a time period. Patients get infusions at specialty pharmacies, centers, etc. where they can get treatment. What I don't know are the side affects as it relates to being able to commute to/from.

True..... but you going to setup rapid COVID treatment centers all over? Who is going to want to be near those?

 

[anon_mlxxvlbug9dpa]

True..... but you going to setup rapid COVID treatment centers all over? Who is going to want to be near those?

Honestly you’d just need some open air tents in open spaces. What the hell are football fields good for right now?

 

[JamieDimonsBalls]

Honestly you’d just need some open air tents in open spaces. What the hell are football fields good for right now?

And going into the summer, 2/3 of the county would be perfect for outdoor.

 

[bawlmer]

And it looks like we won't have to share the supply with the UK for awhile (link).

 

[UncleMark]

Honestly you’d just need some open air tents in open spaces. What the hell are football fields good for right now?

They could move that hospital ship from NYC to the Jordan River.