They have depth to have a decent Center playing on Saturday. But Center is a pretty impactful position to lose, at this point in the season. And the domino effect it COULD have, by having to move guys around, could hit them hard.
The flip side for a school like OSU, with as much depth of talent as they have, they very easily could "discover" a gamer that comes in and takes over and thrives. Ohio State depth is not the same as IU depth. They have a stable of 4+ star offensive linemen, and I'm sure they have the potential for one of them to "step up" and be incredibly effective on Saturday. Whoever is inserted will have fresher legs, and certainly will be amped up.
I'm reminded of this from time to time from my college bball days. We had a guy on our bench that was incredibly talented, but was buried on the bench because he was lazy, at times, and overall very inconsistent. In the middle of the season, we had a combination of a couple injuries, and a couple suspensions, and he literally HAD to play in a game against one of the better teams in the nation. He had 25 points, 12 rebounds...and we nearly knocked that team off because of it, because of his performance. No one on that team thought he deserved to start or play more minutes. And he went right back to being lazy and inconsistent after that game. But man, for that one day, he was a stud.
On OSU lineman buried on the depth chart for whatever reasons, could easily have a day like that on Saturday.