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We're only in the second inning of the pandemic.

sglowrider

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Winston Churchill: "This is not the end. It is not even the beginning of the end, but it's perhaps the end of the beginning."

Infectious disease expert Michael Osterholm, who has been warning for a decade and a half about the possibility of a global pandemic, said the coronavirus we're fighting is at least as infectious as the one that killed an estimated 50 million people in the 1918 flu worldwide outbreak.

He said we're only in the second inning of a nine-inning contest, with the possibility of as many as 800,000 deaths or more in the US over the next 18 months.

Osterholm also pointed to a shortage of chemical reagents that are necessary for widespread testing for the virus and said that the CDC's low public profile in this pandemic in the United States has been a "tragedy."

He decried the lack of a national long-term strategy for the pandemic and noted that there are real questions about the efficacy of the antibody tests that are being developed to detect if people have been exposed to the virus.

....................

There are 320 million people in the United States. If half of them get infected in the next 6 to 18 months, that's 160 million people. The 50% rate of infection over the course of the pandemic is at the low end of my colleagues' consensus on what we can expect to see given the infectiousness of this virus.

Based on what we know from Asia, from the European Union and from the United States, about 80% of these cases will have asymptomatic, mild or moderate illness but won't need professional medical care. About 20% of infected people will seek medical care. That's 32 million people.

Of those, about half will be hospitalized. That's 16 million people. Of those who are hospitalized, about half will actually require some form of critical care. That's 8 million people. About 0.5 to 1% of the total number of 160 million infected people will die. So you have the possibility of at least 800,000 deaths in the US over the next 18 months.

This is the number of deaths I'm expecting.

If you don't like the numbers I just used, go ahead and change them however you want. Just provide your justification. We have a long way to go with this pandemic.

We just need to make people understand that this is going to be bad until we get a safe, effective and widely available vaccine.
It's a sad commentary about our state of affairs that the number of people who die from Covid-19 in the US ranks as one of the top daily causes of death -- on some days it's been ranked higher than heart disease, cancer and accidents. Six weeks ago, it wasn't even in the top 60 causes of deaths.



https://edition.cnn.com/2020/04/21/opinions/bergen-osterholm-interview-two-opinion/index.html
 
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“I’m afraid that the most likely scenario is that we will not have a vaccine before the end of next year,” Schwan said on a Wednesday conference call with reporters, adding that an 18-month timeline is “very ambitious.”

He said that an antibody test, rather than a vaccine, would be key to allowing people to return to normal life before 2021.

The blood tests, which Roche plans to launch in May, can determine whether someone has had COVID-19, the illness caused by the coronavirus, and is likely immune to the virus. That could allow the population to gradually return to work.

Some researchers are more optimistic that a vaccine will be produced this year.
 
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“I’m afraid that the most likely scenario is that we will not have a vaccine before the end of next year,” Schwan said on a Wednesday conference call with reporters, adding that an 18-month timeline is “very ambitious.”

He said that an antibody test, rather than a vaccine, would be key to allowing people to return to normal life before 2021.

The blood tests, which Roche plans to launch in May, can determine whether someone has had COVID-19, the illness caused by the coronavirus, and is likely immune to the virus. That could allow the population to gradually return to work.

Some researchers are more optimistic that a vaccine will be produced this year.
We have a flu vaccine and we still incur tens of thousands of deaths every year. Viral mutations and individual reticence to get vaccinations make holding out for a vaccine a pipe dream. The key to getting past this will be the efficacy of therapeutics, any of which are currently being studied, or perhaps haven't been imagined yet.
 
Winston Churchill: "This is not the end. It is not even the beginning of the end, but it's perhaps the end of the beginning."

Infectious disease expert Michael Osterholm, who has been warning for a decade and a half about the possibility of a global pandemic, said the coronavirus we're fighting is at least as infectious as the one that killed an estimated 50 million people in the 1918 flu worldwide outbreak.

He said we're only in the second inning of a nine-inning contest, with the possibility of as many as 800,000 deaths or more in the US over the next 18 months.

Osterholm also pointed to a shortage of chemical reagents that are necessary for widespread testing for the virus and said that the CDC's low public profile in this pandemic in the United States has been a "tragedy."

He decried the lack of a national long-term strategy for the pandemic and noted that there are real questions about the efficacy of the antibody tests that are being developed to detect if people have been exposed to the virus.

....................

There are 320 million people in the United States. If half of them get infected in the next 6 to 18 months, that's 160 million people. The 50% rate of infection over the course of the pandemic is at the low end of my colleagues' consensus on what we can expect to see given the infectiousness of this virus.

Based on what we know from Asia, from the European Union and from the United States, about 80% of these cases will have asymptomatic, mild or moderate illness but won't need professional medical care. About 20% of infected people will seek medical care. That's 32 million people.

Of those, about half will be hospitalized. That's 16 million people. Of those who are hospitalized, about half will actually require some form of critical care. That's 8 million people. About 0.5 to 1% of the total number of 160 million infected people will die. So you have the possibility of at least 800,000 deaths in the US over the next 18 months.

This is the number of deaths I'm expecting.

If you don't like the numbers I just used, go ahead and change them however you want. Just provide your justification. We have a long way to go with this pandemic.

We just need to make people understand that this is going to be bad until we get a safe, effective and widely available vaccine.
It's a sad commentary about our state of affairs that the number of people who die from Covid-19 in the US ranks as one of the top daily causes of death -- on some days it's been ranked higher than heart disease, cancer and accidents. Six weeks ago, it wasn't even in the top 60 causes of deaths.



https://edition.cnn.com/2020/04/21/opinions/bergen-osterholm-interview-two-opinion/index.html


So, do we believe Fauci, Redfield, this dude?
 
We have a flu vaccine and we still incur tens of thousands of deaths every year. Viral mutations and individual reticence to get vaccinations make holding out for a vaccine a pipe dream. The key to getting past this will be the efficacy of therapeutics, any of which are currently being studied, or perhaps haven't been imagined yet.
Nope.
 
Winston Churchill: "This is not the end. It is not even the beginning of the end, but it's perhaps the end of the beginning."

Infectious disease expert Michael Osterholm, who has been warning for a decade and a half about the possibility of a global pandemic, said the coronavirus we're fighting is at least as infectious as the one that killed an estimated 50 million people in the 1918 flu worldwide outbreak.

He said we're only in the second inning of a nine-inning contest, with the possibility of as many as 800,000 deaths or more in the US over the next 18 months.

Osterholm also pointed to a shortage of chemical reagents that are necessary for widespread testing for the virus and said that the CDC's low public profile in this pandemic in the United States has been a "tragedy."

He decried the lack of a national long-term strategy for the pandemic and noted that there are real questions about the efficacy of the antibody tests that are being developed to detect if people have been exposed to the virus.

....................

There are 320 million people in the United States. If half of them get infected in the next 6 to 18 months, that's 160 million people. The 50% rate of infection over the course of the pandemic is at the low end of my colleagues' consensus on what we can expect to see given the infectiousness of this virus.

Based on what we know from Asia, from the European Union and from the United States, about 80% of these cases will have asymptomatic, mild or moderate illness but won't need professional medical care. About 20% of infected people will seek medical care. That's 32 million people.

Of those, about half will be hospitalized. That's 16 million people. Of those who are hospitalized, about half will actually require some form of critical care. That's 8 million people. About 0.5 to 1% of the total number of 160 million infected people will die. So you have the possibility of at least 800,000 deaths in the US over the next 18 months.

This is the number of deaths I'm expecting.

If you don't like the numbers I just used, go ahead and change them however you want. Just provide your justification. We have a long way to go with this pandemic.

We just need to make people understand that this is going to be bad until we get a safe, effective and widely available vaccine.
It's a sad commentary about our state of affairs that the number of people who die from Covid-19 in the US ranks as one of the top daily causes of death -- on some days it's been ranked higher than heart disease, cancer and accidents. Six weeks ago, it wasn't even in the top 60 causes of deaths.



https://edition.cnn.com/2020/04/21/opinions/bergen-osterholm-interview-two-opinion/index.html
I just wish Trump would play left out.
 
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We have a flu vaccine and we still incur tens of thousands of deaths every year. Viral mutations and individual reticence to get vaccinations make holding out for a vaccine a pipe dream. The key to getting past this will be the efficacy of therapeutics, any of which are currently being studied, or perhaps haven't been imagined yet.

We have therapeutics for the flu "and we still incur tens of thousands of deaths every year". Is there a reason to think a therapeutic for COVID will work better?

One issue with Tamiflu is one must take it very early in the illness for it to make much difference. IF treatments for COVID are similar, it creates a similar problem. People who are poor and without insurance will first opt to ride it out. It may turn out that therapeutics need taken before the really bad symptoms arrive.
 
We have therapeutics for the flu "and we still incur tens of thousands of deaths every year". Is there a reason to think a therapeutic for COVID will work better?.
Yes, there are a dizzying array of very different flu viruses that can crop up, and top scientists make an educated guess as to what might be a dominant strain in any season, making this guess months in advance. So... usually the vaccine only partly gets it right. Plus people underestimate risk of flu death and are lackadaisical about getting the shot, or are misinformed by pseudoscience.

The virus causing COVID-19 is a defined coronovirus with a known and (apparently) immutable mechanism for human infection. Sure, it mutates. A lot, actually, since for a virus it has a large genome. But hasn't been shown to be able to substantially mutate in the spike region and retain efficacy. If antibodies can be generated to target the spike protein or (even better) the receptor binding domain of the spike protein, the odds of long-term effectiveness will be high.

But then, if we don't get a grip on global wildlife habitat destruction and take climate change seriously, the next virus will emerge within this decade, and we'll just do this all over again.
 
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