Moderna vaccine interim results: 94% efficacy

[outside shooter]

Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study | Moderna, Inc.

First interim analysis included 95 participants with confirmed cases of COVID-19 Phase 3 study met statistical criteria with a vaccine efficacy of 94.5% (p

investors.modernatx.com

analysis: https://blogs.sciencemag.org/pipeline/archives/2020/11/16/modernas-vaccine-efficacy-readout

executive summary:
-95 total cases in the trial to date, split 90/5 between the control group and the vaccinated group.
-11 of 95 were severe infections: all 11 were in the controls and zero in the vaccine patients.
-“generally short lived” side effects noted: fatigue in 9.7% of patients, myalgia (muscle pain) in 8.9%, arthralgia (joint pain) in 5.2%, headache in 4.5%, and just “pain” in 4.1%.

2nd pres release: https://investors.modernatx.com/new...ounces-longer-shelf-life-its-covid-19-vaccine

-Moderna says that new stability testing shows that their vaccine remains stable for up to six months under standard freezer conditions, up to 30 days under standard refrigeration conditions, and up to 12 hours at room temperature. There’s no dilution or further handling at the point of administration. This is much more like what you want to see, as compared to the more demanding storage conditions that seem to be needed for the Pfizer candidate. This is how a lot of medicine (and food, for that matter) is already distributed and stored – our infrastructure is a lot more prepared for this.

right now the vaccine news is very good indeed.

 

[stollcpa]

Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study | Moderna, Inc.

First interim analysis included 95 participants with confirmed cases of COVID-19 Phase 3 study met statistical criteria with a vaccine efficacy of 94.5% (p

investors.modernatx.com

analysis: https://blogs.sciencemag.org/pipeline/archives/2020/11/16/modernas-vaccine-efficacy-readout

executive summary:
-95 total cases in the trial to date, split 90/5 between the control group and the vaccinated group.
-11 of 95 were severe infections: all 11 were in the controls and zero in the vaccine patients.
-“generally short lived” side effects noted: fatigue in 9.7% of patients, myalgia (muscle pain) in 8.9%, arthralgia (joint pain) in 5.2%, headache in 4.5%, and just “pain” in 4.1%.

2nd pres release: https://investors.modernatx.com/new...ounces-longer-shelf-life-its-covid-19-vaccine

-Moderna says that new stability testing shows that their vaccine remains stable for up to six months under standard freezer conditions, up to 30 days under standard refrigeration conditions, and up to 12 hours at room temperature. There’s no dilution or further handling at the point of administration. This is much more like what you want to see, as compared to the more demanding storage conditions that seem to be needed for the Pfizer candidate. This is how a lot of medicine (and food, for that matter) is already distributed and stored – our infrastructure is a lot more prepared for this.

right now the vaccine news is very good indeed.

I guess Cuomo changed his mind after the election.

Gov. Cuomo Doubles Down On New York Vaccine Squabble, Floats Suing White House If Doses Withheld – CBS New York

Gov. Andrew Cuomo heated up his battle with the White House over the tens of millions of COVID-19 vaccine doses needed for the state, saying Sunday he's poised to sue if the rollout is withheld.

newyork.cbslocal.com

 

[outside shooter]

I guess Cuomo changed his mind after the election.

He has been 100% consistent: listen to the scientists directly, and not to the buffoonish realty TV show guy, who hasn't even met with the scientists in several months but has continually tried to manipulate the science for his failed reelection efforts.

But this thread was not about politics. Keep up.

It's about finding a way out of this mess.

 

[hoosboot]

Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study | Moderna, Inc.

First interim analysis included 95 participants with confirmed cases of COVID-19 Phase 3 study met statistical criteria with a vaccine efficacy of 94.5% (p

investors.modernatx.com

analysis: https://blogs.sciencemag.org/pipeline/archives/2020/11/16/modernas-vaccine-efficacy-readout

executive summary:
-95 total cases in the trial to date, split 90/5 between the control group and the vaccinated group.
-11 of 95 were severe infections: all 11 were in the controls and zero in the vaccine patients.
-“generally short lived” side effects noted: fatigue in 9.7% of patients, myalgia (muscle pain) in 8.9%, arthralgia (joint pain) in 5.2%, headache in 4.5%, and just “pain” in 4.1%.

2nd pres release: https://investors.modernatx.com/new...ounces-longer-shelf-life-its-covid-19-vaccine

-Moderna says that new stability testing shows that their vaccine remains stable for up to six months under standard freezer conditions, up to 30 days under standard refrigeration conditions, and up to 12 hours at room temperature. There’s no dilution or further handling at the point of administration. This is much more like what you want to see, as compared to the more demanding storage conditions that seem to be needed for the Pfizer candidate. This is how a lot of medicine (and food, for that matter) is already distributed and stored – our infrastructure is a lot more prepared for this.

right now the vaccine news is very good indeed.

It means one of two things:

1) If you take both this and the Pfizer vaccine, the treatment will be 184% effective

or

2) stoll remains angry and butthurt.

Good news about the Moderna vaccine as it continues to look like flowers blooming in Spring 2021 will have multiple meanings. 🎉🎈💉💥🌈🌞

Bad news about stoll.

 

[outside shooter]

sorry for the duplicate discussion, I didn't see it posted in the "Dow Jones" thread.

 

[iuwclurker]

Sell your stock in Pfizer quicklike.

 

[outside shooter]

Sell your stock in Pfizer quicklike.

There's room enough for both

 

[UncleMark]

Sell your stock in Pfizer quicklike.

There's room enough for both

Yeah, since cost has been taken out of the equation, both can proceed in parallel. But as mentioned elsewhere, they'll most likely be used for different populations because of the different distribution hurdles.

 

[CO. Hoosier]

He has been 100% consistent: listen to the scientists directly, and not to the buffoonish realty TV show guy, who hasn't even met with the scientists in several months but has continually tried to manipulate the science for his failed reelection efforts.

But this thread was not about politics. Keep up.

It's about finding a way out of this mess.

Dumb.

Anyone always has direct access to what the scientists say. Cuomo deliberately chose to use vaccines to bash Trump because that’s what Coumo preferred to do.

 

[Courtsensetwo]

Yeah, since cost has been taken out of the equation, both can proceed in parallel. But as mentioned elsewhere, they'll most likely be used for different populations because of the different distribution hurdles.

Well done. Polite golf applause.

You have potential grasshoppa

 

[meridian]

He has been 100% consistent: listen to the scientists directly, and not to the buffoonish realty TV show guy, who hasn't even met with the scientists in several months but has continually tried to manipulate the science for his failed reelection efforts.

But this thread was not about politics. Keep up.

It's about finding a way out of this mess.

Stoll can't help it! It is his nature.

 

[outside shooter]

Anyone always has direct access to what the scientists say.

Fauci was bound and gagged for months. Virtually every request to interview him was denied by the White House. We were supposed to settle for Trump relaying scientific information. That got us recommendations to shove lightbulbs where the sun don't shine, so it would meet up with the bleach that you inject.

 

[Marvin the Martian]

We have to hope people will take the vaccine. The Twitter account below purports to be a South Dakota medical worker. Patients in the hospital struggling to breathe yelling at medical staff it cannot be COVID because COVID is not real. Are they going to vaccinate?

 

[mcmurtry66]

We have to hope people will take the vaccine. The Twitter account below purports to be a South Dakota medical worker. Patients in the hospital struggling to breathe yelling at medical staff it cannot be COVID because COVID is not real. Are they going to vaccinate?

View embedded media

If it’s 95 percent effective does it matter if some percentage (25 or whatever) doesn’t get it?

 

[outside shooter]

Wow, Marv... I hope that everyone reads that twitter thread.

 

[Marvin the Martian]

If it’s 95 percent effective does it matter if some percentage (25 or whatever) doesn’t get it?

I hope it is 25%. Between the normal antivaxxers, the "it is a hoax to embarrass Trump" and "I don't trust anything Trump's government touched" crowds we may get to 50%. That probably is enough to really slow spread bit we should do better.

 

[outside shooter]

If it’s 95 percent effective does it matter if some percentage (25 or whatever) doesn’t get it?

It will take heroic efforts to get 75% of the people to take it. Polls I have seen are closer to 50-50.

 

[mcmurtry66]

It will take heroic efforts to get 75% of the people to take it. Polls I have seen are closer to 50-50.

okay not to be a d*ck but that's their problem right? F em? because if my fam takes it we're 95% good irrespective of what anyone else does. right?

 

[HillzHoozier]

It will take heroic efforts to get 75% of the people to take it. Polls I have seen are closer to 50-50.

Add in the 10% of folks who've recovered and there's your herd immunity.

 

[Harry Hondo]

okay not to be a d*ck but that's their problem right? F em? because if my fam takes it we're 95% good irrespective of what anyone else does. right?

yes, but the virus would still be a pretty big problem and would still weigh pretty heavy on society as a whole. to achieve herd immunity and eradicate the virus you'd need 65-70%, at least, taking the vaccine.

 

[Marvin the Martian]

okay not to be a d*ck but that's their problem right? F em? because if my fam takes it we're 95% good irrespective of what anyone else does. right?

Not everyone can get vaccinated. Some people have legitimate health conditions and are not recommended to get vaccines. They would still be at risk.

 

[82hoosier]

it will be a real blow to the GOP, when with benefit of hindsight, folks realize that it was mostly Trumpsters that got sick and died in the second half of 2021.

 

[outside shooter]

 

[Harry Hondo]

Add in the 10% of folks who've recovered and there's your herd immunity.

there's no evidence that people are immune after recovering from the virus. obviously you haven't been paying attention to the science.

 

[CO. Hoosier]

yes, but the virus would still be a pretty big problem and would still weigh pretty heavy on society as a whole. to achieve herd immunity and eradicate the virus you'd need 65-70%, at least, taking the vaccine.

How could it be a problem for society as a whole if 50% are vaccinated? If I have a 90%+ chance of being in the clear, I’m gonna live pretty much normally. That makes the virus a problem for only a minority of society, right?

 

[CO. Hoosier]

there's no evidence that people are immune after recovering from the virus. obviously you haven't been paying attention to the science.

Don’t recovered patients have antibodies? Doesn’t that confer immunity for an indeterminate time? Plasma treatment from recovered patients is a therapeutic right?

 

[Marvin the Martian]

Because I have it, in smallpox days police would hold people down in vaccine raids so the medical people could give the shots. Yet a Supreme Court Justice said in the past few days that COVID is an unparalleled assault on civil liberties. I guess lawyers do not read history.

 

[HillzHoozier]

there's no evidence that people are immune after recovering from the virus. obviously you haven't been paying attention to the science.

Actually I've been paying very close attention. The only question is how long immunity lasts. The number of people reinfected is so few they could fit in the same elevator. There's much more evidence regarding longevity of immunity following natural exposure/recovery than exists about any of the vaccines.

 

[HillzHoozier]

Don’t recovered patients have antibodies? Doesn’t that confer immunity for an indeterminate time? Plasma treatment from recovered patients is a therapeutic right?

Plasma treatment has not proven to be very effective.

 

[Courtsensetwo]

How did this turn into a political food fight?

 

[CO. Hoosier]

How did this turn into a political food fight?

Food fight would be a step up.

 

[anon_mlxxvlbug9dpa]

We have to hope people will take the vaccine. The Twitter account below purports to be a South Dakota medical worker. Patients in the hospital struggling to breathe yelling at medical staff it cannot be COVID because COVID is not real. Are they going to vaccinate?

View embedded media

Yeah I’m gonna go ahead and call BS on that lady. While some severely mentally ill people might behave the way she’s explaining - it’s almost impossible for it to be happening at scale. People are dumb but not that dumb.

 

[ButHerEmails]

there's no evidence that people are immune after recovering from the virus. obviously you haven't been paying attention to the science.

A few studies I’ve seen show an almost total loss of antibodies in ~3 months. Then there are the documented cases of reinfection. There’s goes herd immunity (mentality).

 

[HillzHoozier]

A few studies I’ve seen show an almost total loss of antibodies in ~3 months. Then there are the documented cases of reinfection. There’s goes herd immunity (mentality).

T-cells linger. Like your AXE body spray.

 

[outside shooter]

A few studies I’ve seen show an almost total loss of antibodies in ~3 months. Then there are the documented cases of reinfection. There’s goes herd immunity (mentality).

Antibodies go away over time after an infection, as well. You get T-cell immunity. which starts making the antibodies from scratch when you need them.

The still-to-come data from a full three months of dosing will establish whether the vaccinated have T-cell mediated immunity. Most people thank that they will, and that it ought to be effective for a while. Whether that is is 6 months, 1 year, or 5 years isn't clear though. It probably won't be, either, until 6+ months have passed for trial patients dosed in September.

 

[Bulk VanderHuge]

Yeah I’m gonna go ahead and call BS on that lady. While some severely mentally ill people might behave the way she’s explaining - it’s almost impossible for it to be happening at scale. People are dumb but not that dumb.

Are you new here?

 

[Marvin the Martian]

Yeah I’m gonna go ahead and call BS on that lady. While some severely mentally ill people might behave the way she’s explaining - it’s almost impossible for it to be happening at scale. People are dumb but not that dumb.

I hope you are right. It turns out CNN interviwed her, you can see if you think she is believable. I make no warranties.

Nurse: Some patients who test positive refuse to believe they have Covid-19 - CNN Video

CNN's Alisyn Camerota speaks with Jodi Doering, a nurse from South Dakota who says some of her coronavirus patients often don't want to believe that Covid-19 is real, even in their dying moments.

www.google.com

 

[82hoosier]

It will take heroic efforts to get 75% of the people to take it. Polls I have seen are closer to 50-50.

Just like the election.☹

 

[Marvin the Martian]

Plasma treatment has not proven to be very effective.

It looks to make a difference if given early. https://www.statnews.com/2020/08/13...hin,the standard for statistical significance.

 

[mcmurtry66]

Following up on my own post guy from Johns Hopkins says we need 65-70 percent to get vaccinated.