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saying now that there's a new "homegrown" strain in calif.Saw that Merck's vaccine candidate flopped and they are pulling the plug on it.
Also, Moderna is developing a booster specifically for the SA variant.
saying now that there's a new "homegrown" strain in calif.
Of course. There are likely many different strains across a country as large as the U.S. Some are more contagious, some less. Some more impactful on the immune system, some less.
None of this is news except the sensational media that is craving and pushing fear.
Funny thing about adjustable wrenches vs a box end made to fit. They usually slip, somewhat fail and round the nut off making it useless.One great thing about RNA vaccines being effective is that for any new strain under the sun, once you have its genetic sequence, you just make the new snippet of RNA that you need, plug it into the same liposome formulation, and you have a booster shot specific to that new strain.
It makes vaccine design like using an adjustable wrench, rather than having a dozen boxed end wrenches.
This is the answer I was seekingOne great thing about RNA vaccines being effective is that for any new strain under the sun, once you have its genetic sequence, you just make the new snippet of RNA that you need, plug it into the same liposome formulation, and you have a booster shot specific to that new strain.
It makes vaccine design like using an adjustable wrench, rather than having a dozen boxed end wrenches.
Any idea what the approval process is when they modify it? Wondering how fast they can respond on FDA side of things.One great thing about RNA vaccines being effective is that for any new strain under the sun, once you have its genetic sequence, you just make the new snippet of RNA that you need, plug it into the same liposome formulation, and you have a booster shot specific to that new strain.
The inactive ingredients, formulation, stability, manufacturing process should all be roughly the same. Thus it ought to be very much streamlined, almost like establishing bioequivalence of a generic drug.Any idea what the approval process is when they modify it? Wondering how fast they can respond on FDA side of things.
Well, my analogy isn't perfect, because you do go in, the second time around, with the precise booster that you need. So it is like owning an adjustable wrench that, when you go to use it, becomes the perfect-fitting box end wrench, every time.Funny thing about adjustable wrenches vs a box end made to fit. They usually slip, somewhat fail and round the nut off making it useless.
A huge slice of the population gets the flu vaccine each year and some people that get the shot still get the flu. If they tested people with the flu the way they are testing people with covid I'm sure we'd find that there are dozens if not more (many more) strains of the flu each year this is unfortunately the nature of the beast.
Funny thing about adjustable wrenches vs a box end made to fit. They usually slip, somewhat fail and round the nut off making it useless.
If we're going with toolbox analogies, how about a socket wrench; same handle, different socket .Well, my analogy isn't perfect, because you do go in, the second time around, with the precise booster that you need. So it is like owning an adjustable wrench that, when you go to use it, becomes the perfect-fitting box end wrench, every time.
Fo once, you know what you're talking about.Funny thing about adjustable wrenches vs a box end made to fit. They usually slip, somewhat fail and round the nut off making it useless.
That started with the protests over the summer...Is this the start of a real life Walking Dead?
I'm a big fan of the Cali Strains myself. Oh wait. Different thread.
Any idea what the approval process is when they modify it? Wondering how fast they can respond on FDA side of things.